Abstract
A practical and highly enantio- (up to 94:6 er) and diastereoselective (up to >20:1 dr) synthesis of γ-butenolides bearing two adjacent stereogenic centers is reported featuring a sequential direct palladium-catalyzed asymmetric allylic alkylation/( E)-selective cross-metathesis/[3,3]-sigmatropic Cope rearrangement from readily available α-substituted (5 H)-furan-2-ones.
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