A Review on the Biocompatibility of PMMA-Based Dental Materials for Interim Prosthetic Restorations with a Glimpse into their Modern Manufacturing Techniques.

Silviu Mirel Pituru,Alexandra Totan,Ana Maria Cristina Tancu,Tudor Spinu,Mihaela Pantea,Iulia-Ioana Stanescu,Ecaterina Ionescu,Marina Imre,Nicoleta Olivia Popoviciu,Maria Greabu

doi:10.3390/ma13132894

Silviu Mirel Pituru, Alexandra Totan + Show 8 more

Open Access

https://doi.org/10.3390/ma13132894

Copy DOI

Journal: Materials	Publication Date: Jun 28, 2020
Citations: 52	License type: CC BY 4.0

Affiliation: Carol Davila University of Medicine and Pharmacy

Abstract

This paper’s primary aim is to outline relevant aspects regarding the biocompatibility of PMMA (poly(methyl methacrylate))-based materials used for obtaining interim prosthetic restorations, such as the interaction with oral epithelial cells, fibroblasts or dental pulp cells, the salivary oxidative stress response, and monomer release. Additionally, the oral environment’s biochemical response to modern interim dental materials containing PMMA (obtained via subtractive or additive methods) is highlighted in this review. The studies included in this paper confirmed that PMMA-based materials interact in a complex way with the oral environment, and therefore, different concerns about the possible adverse oral effects caused by these materials were analyzed. Adjacent to these aspects, the present work describes several advantages of PMMA-based dental materials. Moreover, the paper underlines that recent scientific studies ascertain that the modern techniques used for obtaining interim prosthetic materials, milled PMMA, and 3D (three-dimensional) printed resins, have distinctive advantages compared to the conventional ones. However, considering the limited number of studies focusing on the chemical composition and biocompatibility of these modern interim prosthetic materials, especially for the 3D printed ones, more aspects regarding their interaction with the oral environment need to be further investigated.

Highlights

An interim restoration represents a fundamental phase in oral prosthetic rehabilitation, aiming to protect the prepared teeth and surrounding soft tissues before a permanent restoration placement and helping the patient to perform essential functions throughout the period amid teeth preparation and application of the final restoration [1,2,3,4]
Cell proliferation is blocked and the apoptotic events are initiated. All these experimental data led us to the conclusion that self-polymerized PMMA resins, despite their advantages, can induce oxidative stress in the exposed pulp cells, which causes oxidative DNA damage, which in turn is a starting point for apoptotic events triggering via P53 and phosphatase and tensin homolog (PTEN) signaling pathways [1,78]
PMMA, which is usually included in the composition of conventional materials used for interim prosthetic restorations, as well as in the modern ones obtained using subtractive or additive technologies, has already proved its clinical performance in the context of obtaining predictable, final prosthetic results, even if their interaction with the oral environment has always been a subject of great interest and debate in the scientific world

Summary

A Review on the Biocompatibility of PMMA-Based

Dental Materials for Interim Prosthetic Restorations with a Glimpse into Their Modern. Silviu Mirel Pituru 1 , Maria Greabu 2 , Alexandra Totan 2 , Marina Imre 3 , Mihaela Pantea 4, *, Tudor Spinu 4, *, Ana Maria Cristina Tancu 3 , Nicoleta Olivia Popoviciu 5 , Iulia-Ioana Stanescu 6 and Ecaterina Ionescu 5

Introduction

PMMA Chemistry

PMMA-Based Dental Materials’ Interaction with Oral Cells and Tissues

Possible Toxic Effects of PMMA-Based Dental Materials on Oral Cells

Findings

Conclusions and Future Perspectives