A review on ophthalmic in - Situ gel

Abstract

The field of ocular drug delivery is one of the most interesting and challenging fields for Formulation Scientists or Pharmacists. In ophthalmic in situ gel many polymers are used which form gel by various mechanisms like pH-sensitive gel and thermo sensitive gel. We can make in situ ocular gel instead of an ophthalmic solution to overcome the problem of low bioavailability. Some common diseases which are cured by in situ ocular gel delivery are blepharitis, conjunctivitis, keratitis, trachoma, glaucoma, etc. The major disadvantages of old formulations such as solutions, suspensions, emulsions, ointments, etc. are poor bioavailability, increased pre-corneal elimination, and high variability in efficacy respectively.