A Review on Nano-Approaches Against Periodontitis Treatment

Abstract

Periodontitis is a provocative condition of the secretions that destroys the alveolar bone, the formation of periodontal pockets, and the degeneration of periodontal ligaments. WHO estimates that between 10 and 15 percent of people worldwide have severe periodontitis. The development of a wide variety of microflora, particularly anaerobes, in the compartments, the release of toxins and enzymes, and the stimulation of the body's immune system are the causes of the disease. Periodontitis was effectively treated using a variety of local or systemic methods. Currently, site-specific delivery, low dose requirements, bypassing first-pass metabolism, a reduction in gastrointestinal side effects, and other factors make the controlled local drug delivery approach preferable to the general approach because it primarily focuses on improving therapeutic outcomes. It offers a safe and efficient way of therapy overall, which improves patient compliance. Various surgical and mechanical procedures completely failed to eradicate the areas' germs. Numerous polymer-based delivery methods, including fibers, films, chips, strips, microparticles, nanoparticles, and nanofibers manufactured from various natural and synthetic materials, have been investigated to successfully transport various medications. These solutions have good mucoadhesion qualities, are Fill the pockets, have high retention at the target site, and are biocompatible and biodegradable. The study gives a general summary of all the different periodontitis targeted delivery systems that are now available and being created.