A Review on Liquisolid: A Novel Technique for Enhancement of Solubility and Bioavailability of Poorly Water-Insoluble Drugs

Abstract

Liquisolid technique is a novel approach that is used for the enhancement of bioavailability and solubility of poorly water insoluble drugs. According to Biopharmaceutical Classification System (BCS), drugs are classified based on their solubility and permeability. Class II and IV drugs have low solubility-high permeability, and low-solubility-low permeability respectively. This issue of solubility has been a major challenge over the years especially for water-insoluble drugs. Liquisolid system involves the formulation of drugs by conversion of liquid drugs, drug suspension or drug solution in non-volatile solvents, to form non-adherent, free flowing and compressible powder mixtures by blending the solution with appropriate carriers and coating materials. The method is most efficient and novel approach for solubility and bioavailability enhancement.