Abstract
A Liquisolid system is the one of the novel technique to enhance the dissolution rate of poorly water soluble drug such as Nateglinide. In this technique liquisolid system refers to formulation of formed by water insoluble drug mix with non-volatile solvent which is further converted into free flowing, non adherent powder form and which is directly compressed into tablets. In that the propylene glycol is used as non-volatile solvent in which drug having high solubility, microcrystalline cellulose and aerosil (silica) acts as carrier and coating material in the ratio of 10:1 and 20:1 respectively. Sodium starch glycolate acts as superdisintegrants and magnesium stearate as glidant in liquisolid system. The prepared liquisolid system were evaluated to their flowing properties such as bulk density, tap density, Hausner’s ratio, Carr’s index, and angle of repose. Fourier Transform Infrared spectroscopy (FTIR) and X Ray Diffraction (XRD) study show no interaction between the drug and excipients. Further tablets were evaluated hardness, diameter, thickness, weight variation, friability, disintegration test, uniformity of contents and in-vitro release study show liquisolid compact exhibited higher percentage of drug release than conventional and marketed tablets because of due to increase in wetting properties and surface availability for dissolution
Highlights
During the last four decades the pharmaceutical industry invested the time and money in study of tablet compaction
Liquisolid compacts is the technique in which the drug is mixed with non-volatile solvent and which is again mixed with carrier and coating material which have specified ratio and added superdisintegrants and Glidant
In literature the liquisolid compacts of Nateglinide is not found the study is selected and other techniques for solubility enhancement are given on this drug such as nanoparticles, solid dispersions
Summary
During the last four decades the pharmaceutical industry invested the time and money in study of tablet compaction. The reason behind it the oral dosage forms are self administered by patient, they more profitable to manufacture than parenteral dosage forms. The poor dissolution rates of water insoluble drugs are still a substantial problem confronting the pharmaceutical industry. Various solid dosage formulation techniques, to enhance the dissolution of poorly soluble substances, have been introduced with different degrees of success. Drug dissolution is the single most important factor in the absorption of it, especially from the most widely used conventional solid dosage forms, tablets and capsules [3,4,5]
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