Abstract
Human plasma vitamin E-binding glycoprotein afamin is mostly produced in the liver and released into the circulation. The review in this study related to a glycoprotein afamin marker that is important in many disease(Type 2 diabetes mellitus,cancer,obesity , Gestational diabetes mellitus,oxidative stress,and metabolic syndrome. Although ovarian follicles and human cerebrospinal fluid also contain sizable amounts of AFM, the liver is the main organ that generates it. Though there are minor AFM manifestations have been also reported in the human heart, testis, brain, kidney, and ovary. Afamin is promising metabolic novel marker for gestational diabetes,type 2 diabetes mellitus cancer,metabolic syndrome,and related disease.
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