In Vivo Evaluation of The Hepatotoxic Disorders of Tributyltin Low Doses in Male Rats

Abstract

Tributyltin (TBT) has been used widely for over 60 years as a pesticidal, preservation, rodent repellent, water-repellant coating, corrosion inhibitor, flame-resistant polyester, and household product. Previous research has demonstrated the toxicity of high doses of TBT, but there is insufficient data on the effects of relevant levels of TBT on at low doses. The main goal of this thesis is to recognize the hepatotoxicity of Sublethal doses of TBT chloride (10-2000 µg/Kg body weight) in male rats for 45 days. TBT induced hepatic induction of oxidative stress as indicated by increasing levels of TBARS and 8-OHdG, induction of hepatic inflammation as indicated by the elevated NF-B levels; inhibition of hepatic expression of PGC-1α and impairment of mitochondrial biogenesis, induction of SREBP-1c and induce hepatic lipogenesis and fatty liver, and distortion of hepatic structure at histological level in a dose-dependent manner significantly at doses higher than 250 µg/kg. In conclusion: the TBT at low doses can induce hepatotoxicity at different levels.