A rapid and specific semi-micro method involving high-pressure liquid chromatography for the assay of metronidazole in plasma, saliva, serum, urine and whole blood.

Abstract

British Journal of Clinical PharmacologyVolume 9, Issue 5 p. 528-529 Free Access A rapid and specific semi-micro method involving high-pressure liquid chromatography for the assay of metronidazole in plasma, saliva, serum, urine and whole blood. CM Kaye, CM KayeSearch for more papers by this authorMG Sankey, MG SankeySearch for more papers by this authorLA Thomas, LA ThomasSearch for more papers by this author CM Kaye, CM KayeSearch for more papers by this authorMG Sankey, MG SankeySearch for more papers by this authorLA Thomas, LA ThomasSearch for more papers by this author First published: May 1980 https://doi.org/10.1111/j.1365-2125.1980.tb05856.xCitations: 36AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References BROGDEN, R.N., HEEL, R.C., SPEIGHT, T.M. & AVERY, G.S. (1978). Metronidazole in anaerobic infections: a review of its activity, pharmacokinetics and therapeutic use. Drugs, 16, 387– 417. GUDAUSKAS, G.A., PALCIC, B. & KONG, S. (1978). The determination of misonidazole, metronidazole and Ro-9963, a class of radiosensitizing agents by HPLC in plasma and urine. Clin. Biochem., 11, P– 8. GULAID, A., HOUGHTON, G.W., LEWELLEN, O.R.W., SMITH, J. & THORNE, P.S. (1978). Determination of metronidazole and its two major metabolites in biological fluids by high pressure liquid chromatography. Br. J. clin. Pharmac., 6, 430– 432. HOUGHTON, G.W., THORNE, P.S., SMITH, J., TEMPLETON, R. & COLLIER, J. (1979). Comparison of the pharmacokinetics of metronidazole in healthy female volunteers following either a single oral or intravenous dose. Br. J. clin. Pharmac., 8, 337– 341. LANBECK, K. & LINDSTROM, B. (1979). Determination of metronidazole and tinidazole in plasma and faeces by high-performance liquid chromatography. J. Chromatogr., 162, 117– 121. MARQUES, R.A., STRAFFORD, B., FLYNN, N. & SADEE, W. (1978). Determination of metronidazole and misonidazole and their metabolites in plasma and urine by high-performance liquid chromatography. J. Chromatogr., 146, 163– 166. STAMBAUGH, J.E., FEO, L.G. & MANTHEI, R.W. (1968). The isolation and identification of the urinary oxidative metabolites of metronidazole in man. J. Pharmac. exp. Ther., 161, 373– 381. WHEELER, L.A., de MEO, M., HALULA, M., GEORGE, L. & HESELTINE, P. (1978). Use of high-pressure liquid chromatography to determine plasma levels of metronidazole and metabolites after intravenous administration. Antimicrobial Agents Chemother., 13, 205– 209. WORKMAN, P., WILTSHIRE, C.R., PLOWMAN, P.N. & BLEEHEN, N.M. (1978). Monitoring salivary misonidazole in man: a possible alternative to plasma monitoring. Br. J. Cancer, 38, 709– 718. Citing Literature Volume9, Issue5May 1980Pages 528-529 ReferencesRelatedInformation