A comparison of the pharmacokinetics of metronidazole in man after oral administration of single doses of benzoylmetronidazole and metronidazole.

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British Journal of Clinical PharmacologyVolume 14, Issue 2 p. 201-206 Free Access A comparison of the pharmacokinetics of metronidazole in man after oral administration of single doses of benzoylmetronidazole and metronidazole. GW Houghton, GW HoughtonSearch for more papers by this authorHK Hundt, HK HundtSearch for more papers by this authorFO Muller, FO MullerSearch for more papers by this authorR Templeton, R TempletonSearch for more papers by this author GW Houghton, GW HoughtonSearch for more papers by this authorHK Hundt, HK HundtSearch for more papers by this authorFO Muller, FO MullerSearch for more papers by this authorR Templeton, R TempletonSearch for more papers by this author First published: August 1982 https://doi.org/10.1111/j.1365-2125.1982.tb01962.xCitations: 16AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References DAVIES, O.L. & GOLDSMITH, P.L. (1972). Analysis of variance. In Statistical methods in research and production, pp. 121– 177. London: Oliver & Boyd. FINEGOLD, S.M. & SUTTER, V.L. (1972). In. Host resistance to commensal bacteria, ed. T. MacPhee, pp. 275– 297. London: Churchill-Livingstone. GALGIANI, J.N., BUSCH, D.F., BRASS, C., RUMANS, L.W., MANGELS, J.I. & STEVENS, D.A. (1978). Bacteroides fragilis endocarditis, bacteremia and other infections treated with oral or intravenous metronidazole. Am. J. Med., 65, 284– 289. GIBALDI, M. & PERRIER, D. (1975). Pharmacokinetics. In Drugs and the Pharmaceutical Sciences, Vol. 1. ed. J. Swarbrick. New York: Marcel Dekker. GULAID, A., HOUGHTON, G.W., LEWELLEN, O.R.W., SMITH, J. & THORNE, P.S. (1978). Determination of metronidazole and its major metabolites in biological fluids by high pressure liquid chromatography. Br. J. clin. Pharmac., 6, 430– 432. HOUGHTON, G.W., SMITH, J., THORNE, P.S. & TEMPLETON, R. (1979a). The pharmacokinetics of oral and intravenous metronidazole in man. J. Antimicrob. Chemother., 5, 621– 623. HOUGHTON, G.W., THORNE, P.S., SMITH, J., TEMPLETON, R. & COLLIER, J. (1979b). Comparison of the pharmacokinetics of metronidazole in healthy female volunteers following either a single oral or intravenous dose. Br. J. clin. Pharmac., 8, 337– 341. HOUGHTON, G.W., THORNE, P.S., SMITH, J., TEMPLETON, R., COLLIER, J., MOESGAARD, F. & LUKKEGAARD-NEILSEN, M. (1979c). The pharmacokinetics of intravenous metronidazole (single and multiple dosing). In Metronidazole: Proceedings of the 2nd International Symposium on Anaerobic Infections, Geneva, 25-27 April, 1979, Intemational Congress and Symposium Series No. 18, pp. 35– 40, eds I. Philips & J. Collier. London: Royal Society of Medicine. INGHAM, H.R., RICH, G.E., SELKON, J.B., HALE, J.H., ROXBY, C.M., BETTY, M.J., JOHNSON, R.W.G. & ULDHALL, P.R. (1975). Treatment with metronidazole of three patients with serious infections due to Bacteroides fragilis. J. Antimicrob. Chemother., 1, 235– 242. KHAN, A.K. & MUAZZAM, M.G. (1964). Diarrhoeal disease (Intestinal flagellates). East Pakistan Med. J., 8, 18– 20. McGILL, M.I. & BLACK, M.D. (1962). Observations on the use of metronidazole in the treatment of trichomoniasis. Am. J. Obstet, Gynec., 83, 1280– 1283. POWELL, S.J. (1969). Metronidazole in the treatment of amoebic dysentery. Med. Today, 3, 48– 53. Citing Literature Volume14, Issue2August 1982Pages 201-206 ReferencesRelatedInformation