Abstract
The increased demand for high specific radioactivity neuroreceptor ligands for positron emission tomography (PET) requires the production of high specific radioactivity carbon-11 in high yields. We have attempted to address this issue with the development of a new quartz-lined aluminium target for the production of [(11)C]methane or [(11)C]carbon dioxide. The new target has been tested with respect to yields of [(11)C]methane and [(11)C]carbon dioxide, and the effect of the quartz liner has been evaluated. The specific radioactivities of a large number of radiopharmaceuticals produced using this target have also been measured. The described target produces [(11)C]-labelled gases in excellent yields, and losses of radioactivity in the target on production of [(11)C]methane have been reduced significantly by the use of a quartz liner. Radiopharmaceuticals with specific radioactivities up to 9000 GBq/μmol at end of bombardment (EOB) (243 Ci/μmol) have been produced using this target. We have developed a reliable, high-yielding carbon-11 gas target which is now routinely used in our department for the production of high specific activity radiopharmaceuticals.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
