Abstract
Positron Emission Tomography: Updates on Imaging of Addiction.
Highlights
Addiction is a disorder in the brain involving a shift from controlled experimentation to a more uncontrolled and compulsive pattern despite harmful consequences [5, 12, 13]
Recent meta-analyses of nuclear medicine neuroimaging studies that compared healthy individuals with users to assess the effects of drugs of abuse on the striatal dopamine system have grouped drugs by whether they are stimulants or sedatives
Lower striatal D2/D3 receptor availability was reported for individuals with amphetamine, methamphetamine, cocaine, alcohol, or opioid use but not for cannabis or nicotine use (Figure 2)
Summary
Addiction is a disorder in the brain involving a shift from controlled experimentation to a more uncontrolled and compulsive pattern despite harmful consequences [5, 12, 13]. Understanding the neural basis of psychoactive substance addiction has required an integrated approach spanning from well-controlled preclinical experiments to clinical studies in cognitive and affective neuroscience [14].
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