A prospective study on one-time use of prophylactic antibiotics for metabolic syndrome patients with inguinal hernia before tension-free repair

Abstract

Objective To explore whether or not the use of prophylactic antibiotics is required before inguinal hernia repair in metabolic syndrome (MS) patients.Methods According to the randomized double blind,prospective study,from 2010 July to 2012 December,186 MS patients underwent inguinal hernia repair operation were selected as the study objects.The control group(n =93) was given a one-time cefazolin 1.5g plus 0.9％ sodium chloride injection 20ml intravenous injection 30min before operation,the observation group(n =93) was given 0.9％ sodium chloride injection 20ml intravenous injection.Results The control group had 5 cases of infection,the observation group had 6 cases.There were no statistically significant differences in the normal body temperature of operation site infection,occurred between the two groups after operation (all P ＞ 0.05).But in the two groups,the probability of infection occurs of the patients with body mass index(WBI) more than 30 was higher that of the patients with 25 ≤WBI ≤ 30(17.24％ vs 1.56％,12.90％ vs 1.61％,x2 =4.69,4.87,all P ＜0.05),the probability of infection occurs of fasting blood glucose(FPG) more than 12.0mmol/L was higher than that of the patients with 6.1mmol/L≤FPG≤ 12.0mtol/L(15.30％ vs 1.64％,13.33％ vs 1.59％,x2 =4.81,5.13,all P＜0.05).Conclusion MS patients underwent tension-free repair of inguinal hernia don't need the use of antibiotics to prevent postoperative surgical site infection(SSI).But for the severe obesity,high blood sugar (FPG ＞ 12.0mmol/L) patients,the preoperation prophylactic antibiotics is necessary,and it can reduce the incidence of postoperative SSI. Key words: Metabolic syndrome X; Hernia, inguinal; Surgical procedures, operative; Antibiotic prophylaxis ; Infection