Abstract
Human biomonitoring provides a scientific approach that systematically reveals exposure to phthalates through all possible routes. In this pilot study, fingernail was chosen as a non-destructive biospecimen to assess human exposure to nine phthalates. Concentrations of total phthalates ranged from 17.8 to 176µg/g (median: 65.4µg/g). Di(2-ethylhexyl) phthalate, dibutyl phthalate (DBP), and di-isobutyl phthalate were the major compounds found in fingernails, accounting for 64.3%, 19.4%, and 12.9% of the total phthalates, respectively. No significant difference in phthalates concentrations was found among genders and age-related distribution (p > 0.05). The concentration of DBP was positively correlated with participant's body mass index (r = 0.83). Our results suggested that fingernail can be used as a non-invasive biospecimen for the biomonitoring of human exposure to phthalates. Further studies are needed to investigate the relationship between phthalates or their metabolites in fingernail and other biological samples, such as urine and blood.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Bulletin of Environmental Contamination and Toxicology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.