Abstract
Five dogs with bilateral hip dysplasia and without osteoarthritis of other joints were enrolled in this pilot study. Objective kinetic data using a pressure sensitive mat and owner assessments using the canine brief pain inventory (CBPI) and Liverpool Osteoarthritis for Dogs (LOAD) questionnaires were obtained prior to treatment. Enrolled dogs were treated in one hip with autologous protein solution (APS) and the contralateral hip was injected with an equal volume of saline. The hip to be treated was selected using a random number generator. At exactly 28 days following treatment dogs were re-assessed using the pressure sensitive mat and the CBPI and LOAD questionnaires. No dogs were treated with any other medications or supplements throughout the study period. Assessment of the total pressure index (TPI) collected using the pressure sensitive mat showed that the hips treated with APS improved significantly more than hips treated with saline (p = 0.0005) and that the hips treated with APS bore significantly more weight than the hips treated with saline at day 28 (p < 0.05). Statistically significant improvement was noted by owners in “pain” and “function” as assessed by the CBPI as well “mobility at exercise” using the LOAD questionnaire. This pilot study provided proof of principle that APS is beneficial in treating pain and lameness in dogs affected by coxofemoral osteoarthritis.
Highlights
Autologous protein solution (APS) is an autologous blood product that is prepared patient-side and is purported to have anti-inflammatory cytokines, such as interleukin receptor-1 antagonist, and anabolic proteins that could be beneficial in the treatment of osteoarthritis (1)
We planned on performing a large study in a uniform population of patients comparing autologous protein solution (APS) to control for treating hip osteoarthritis in dogs
Note that one dog was excluded because the dog met all inclusion criteria with regard to radiography, joints affected, and history, the dog was visibly asymmetrical and predominantly lame on one pelvic limb based upon subjective gait evaluation
Summary
Autologous protein solution (APS) is an autologous blood product that is prepared patient-side and is purported to have anti-inflammatory cytokines, such as interleukin receptor-1 antagonist, and anabolic proteins that could be beneficial in the treatment of osteoarthritis (1). Previous studies in horses (1) and dogs (2), provide initial evidence that intra-articular administration of APS can be effective in reducing pain and lameness in these species when compared to intra-articular saline controls. The study performed in dogs (2) did not include a uniform population of patients with regard to the affected joints, the underlying pathology, or whether. None of the dogs in that study had hip osteoarthritis. We planned on performing a large study in a uniform population of patients comparing APS to control for treating hip osteoarthritis in dogs. Prior to initiating a large, lengthy, and costly study, we sought to perform a pilot study in a limited number of dogs to evaluate study methodology and feasibility, as well as to facilitate performing a power analysis for a larger study
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