Abstract
Introduction: Quantum dots (QDs) are fluorescent semiconductor nanocrystals with unique photophysical properties that can overcome many of the limitations of the current tracers for sentinel lymph node biopsy (SLNB) including the blue dye and radiocolloid. QDs emitting in the Near Infra Red (NIR) can be visualized in deep tissues as the biological window is transparent to these wavelengths. However, the major limitation to their clinical application is their inherent toxicity. We have developed a novel polymer emulsion based on Polyhedral Oligomeric Silsesquioxane Poly (carbonate-urea) Urethane (POSS-PCU) that can be used to coat quantum dots to nullify their toxicity and enhance photostability.
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