Next generation stent coatings: convergence of biotechnology and nanotechnology

Alexander M Seifalian,Aaron Tan,Mohammad S Alavijeh

doi:10.1016/j.tibtech.2012.05.004

Abstract

The advent of percutaneous coronary intervention (PCI) as a less invasive method to coronary artery bypass graft (CABG) surgery has revolutionized the field of interventional cardiology. The use of metal stents as supporting structures, in addition to balloon angioplasty, for maintaining the patency of blocked coronary vessels was first pioneered in 1986 [1]. Before the introduction of drug-eluting stents (DES), bare-metal stents (BMS) were the mainstay in coronary stenting procedures. Indeed, coronary stenting accounted for 84.2% of all PCI procedures in 1999, and by 2005, 90% of stenting procedures were made using a DES [2].

Highlights

MiRNAs are small noncoding RNAs between 18 and 24 nucleotides in length that are transcribed either individually or in clusters from RNA polymerase II (RNA Pol II) promoters, yielding a primary transcript
Based on these initial exciting proofs-of-principle of the functional importance of Chinese hamster ovary (CHO) miRNAs and the tools that are at hand including genomics, transcriptomics, and proteomics, further breakthroughs are soon to be expected
Because miRNAs are only one of many noncoding RNA species that do not add onto the translational burden that recombinant producer cells already have to bear, we are convinced that other noncoding RNAs will hold additional promises for engineering the ‘perfect’ host cell

Summary

Introduction

MiRNAs are small noncoding RNAs between 18 and 24 nucleotides in length that are transcribed either individually or in clusters from RNA polymerase II (RNA Pol II) promoters, yielding a primary transcript. 3 Xu, X. et al (2011) The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line. Generation stent coatings: convergence of biotechnology and nanotechnology

Results

Conclusion