Abstract
A comprehensive study was carried out on Penicillium brocae G2131, which originated from Yunnan Menghai Pu’er tea. This study resulted in the identification of five compounds, one of which is a newly discovered compound: (5aR)-6-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-5a-methyl-5,5a,6,7,8,8a-hexa hydro-2H-indeno[5,4-b]furan-2-one (1), four known compounds: demethylincisterol A3 (2), (22E, 24 R)-ergosta-7,9(11),22-trien-3β-ol (3), (22E,24R)-5α,8α-epidixyer-gosta-6,22-dien-3β-ol (4) and p- hydroxybenzaldehyde (5). The structure of compound 1 was determined using a variety of spectroscopic methods such as 1H spectrum,13C spectrum, HMBC, HSQC,1H-1H COSY, LC-MS, UV, IR and comparison of their NMR data with literature. The absolute configuration of compound 1 was established by comparing the experimental and ECD spectra. All compounds were tested for their anti-acetylcholine activity, however, none of them demonstrated any anti-acetylcholine activity.
Published Version
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