Abstract
In this current paper, a 3D lanthanide (Ln) coordination polymer (CP), compound 1 with a chemical formula of [(NH 2 (Me) 2 )] 6 ·[Gd 3 (TATAT) 2 (μ 2 -O) 1.5 ]·3EtOH·7.5H 2 O is synthesized with the reaction between GdCl 3 ·6H 2 O and 5,5′,5′′-(1,3,5-triazine-2,4,6-triyltriimino)tris(azanediyl) triisophthalate (H 6 TATAT). Its treatment activity and nursing value against ovarian cancer is tested and the associated mechanism is analyzed simultaneously. At first, the CCK-8 detection is implemented to determine the suppression activity of compound 1 against the cell viability of ovarian cancer after treated via our compound. Furthermore, in order to detect the relative expression for the estrogen receptor on cells of ovarian cancer, real time RT-PCR is carried out.
Published Version
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