Abstract
BackgroundPsychiatric diseases severely affect the quality of patients’ lives and bring huge economic pressure to their families. Also, the great phenotypic variability among these patients makes it difficult to investigate the pathogenesis. Nowadays, bioinformatics is hopeful to be used as an effective tool for the diagnosis of psychiatric disorders, which can identify sensitive biomarkers and explore associated signaling pathways.MethodsIn this study, we performed an integrated bioinformatic analysis on 1945 mental-associated proteins including 91 secreted proteins and 593 membrane proteins, which were screened from the Universal Protein Resource (Uniport) database. Then the function and pathway enrichment analyses, ontological classification, and constructed PPI network were executed.ResultsOur present study revealed that the majority of mental proteins were closely related to metabolic processes and cellular processes. We also identified some significant molecular biomarkers in the progression of mental disorders, such as HRAS, ALS2, SLC6A1, SLC39A12, SIL1, IDUA, NEPH2 and XPO1. Furthermore, it was found that hub proteins, such as COMT, POMC, NPS and BDNF, might be the potential targets for mental disorders therapy. Finally, we demonstrated that psychiatric disorders may share the same signaling pathways with cancers, involving ESR1, BCL2 and MAPK3.ConclusionOur data are expected to contribute to explaining the possible mechanisms of psychiatric diseases and providing a useful reference for the diagnosis and therapy of them.
Highlights
Psychiatric diseases severely affect the quality of patients’ lives and bring huge economic pressure to their families
The associated proteins and signaling pathaways were identified by bioinformatic analysis After the DAVID functional annotation clustering, a total of 1075 GO terms were found to be associated with psychiatric diseases proteins
The result demonstrated that mental-disorder-associated proteins mainly enriched in 2 GO categories including biological process (BP) and cellular component (CC)
Summary
Psychiatric diseases severely affect the quality of patients’ lives and bring huge economic pressure to their families. Two thirds of psychiatric patients take physical examination at primary care facilities. They always complain about the lack of energy as well as general aches and pains, so that their doctors usually focus on the organic disorders but neglect the mental problems. Most kinds of psychiatric disorders often present similar symptoms, which frequently delays the early evaluation of neurodevelopment status and disease progression. To this day, the diagnosis of psychiatric diseases has mainly depended on the daily living experience of patients’ families and the subjective expression of patients.
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