Abstract
A mangrove derived Streptomyces strain SACC-152 isolated from Andaman and Nicobar Islands was investigated for its multiple bioactive and biosynthetic properties. Morphology, cultural, physiological and molecular studies showed that the strain SACC-152 is closely similar to Streptomyces maritimus. Bioactive metabolites from the strain SACC-152 were produced by submerged fermentation and extracted using ethyl acetate. The ethyl acetate extract of strain SACC-152 exhibited a broad spectrum of antimicrobial activity against various bacterial and fungal pathogens. Luciferase Reporter Phage (LRP) assay showed more than 80% inhibition against Mycobacterium tuberculosis H37Rv, drug sensitive and multi drug resistant (MDR) M. tuberculosis strains. In MTT assay, the extract showed promising activity against HT-29 colon cancer cell lines with the IC50 value of 9.68
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