Effect of curcumin and turmeric powder on lipid profile of wistar rats (Rattus norvegicus ) induced high fat diet

Abstract

Consumption of foods high in fat is a factor in the occurrence of hyperlipidemia. Hyperlipidemia is characterized by high levels of triglycerides, cholesterol, and Low Density Lipoprotein (LDL) in the blood. The use of curcumin and powder in many studies can reduce cholesterol, triglycerides (TG), and Low Density Lipoprotein (LDL) and increase High Density Lipoprotein (HDL) through antioxidant activity and increase cholesterol absorption. This study aims to compare the hypolipidemic activity of curcumin and turmeric powder in wistar rats fed by high-fat diet. Curcumin (dose 0.34 mg / 50 g BW) and turmeric powder (54 mg / 50 g BW) were given orally for 9 weeks to 2 week old Wistar rats which were fed high fat diet. Triglyceride, cholesterol, and LDL levels were at normal levels for all treatments. Wistar rats fed high-fat diets did not show hyperlipidemia conditions (TG 68.7 mg / dl, cholesterol 80.5 mg / dl, LDL 19.5 mg / dl ). Cholesterol levels of wistar rats given curcumin 98.7 mg / dl. Cholesterol level of Wistar rats given turmeric powder was 86.5 mg / dl. The results showed that oral administration of curcumin or turmeric powder was not significant in reducing hyperlipidemia.