Abstract
In this work, a novel molecularly imprinted electrochemical aptasensor (MIEAS) was developed for highly selective detection of dexamethasone (Dex) in natural water environment. Gold nanoparticles (AuNPs) modified by nitrogen doped molybdenum carbide-graphene (N–Mo2C-Gr) were employed as the supports, where N–Mo2C-Gr improved the conductivity of the electrode and provided a larger specific surface area to polymerize more active substances. Using Dex as template molecule, o-phenylenediamine (o-PD) as the chemical functional monomer and aptamer as the biofunctional monomer, a molecularly imprinted polymer (MIP) membrane with Dex specific recognition sites was formed by electropolymerization. Due to the synergistic effect of MIP and aptamers, the as-prepared MIEAS exhibited a decent linear relationship to Dex detection within a relatively wide range of 10−13 – 10−5 M, and the detection limit was 1.79 × 10−14 M. The recovery in actual water and tablet samples is satisfactory, which confirms the potential application prospects of this sensor in the determination of Dex.
Published Version
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