Abstract
Metal nanoparticles trapped in a biopolymer composite due to electrical conductivity properties improve electrochemical sensors with biomedical and environmental applications. The study aims are to design a novel molecularly imprinted polymer (MIP) composite based on magnetic graphene oxide (Fe3O4@GO) modified silica (SiO2) and gold nanoparticles (AuNPs) to electrochemical detect serotonin (5-hydroxytryptamine, 5-HT). A suitable amount of 5-HT is effective on motivational functions and the environment because it is a serotonergic neurotransmitter. But the desired nanocomposite may have a relatively low recognition, therefore must be in choosing the type of functional monomer be careful. In this regard, the design of the electrochemical sensor began by synthesis of Fe3O4@GO-SiO2@AuNPs nanocomposite. Then, MIP electropolymerization was carried out by using p-aminothiophenol (PATP)-functionalized Fe3O4@GO-SiO2@AuNPs nanocomposite in the presence of 5HT as a template molecule. Electrochemical polymerization of MIP nanocomposite was developed using cyclic voltammetry (CV) and the electrochemical properties of 5-HT were studied use differential pulse voltammetry (DPV) technology in the 5HT solution. After optimization of preparation and measurement conditions on the designed sensor, the 5HT concentration range is 0.1 μM to 10 μM linearly, and the detection limit was 1 × 10-5 μM (S / N = 3). The wide concentration range and low detection limit were presented metal nanoparticles functionalized MIP with appropriate functional monomer have a great effect on the performance of the sensor. Furthermore, PATP-functionalized metal nanoparticles increase the conductivity and recognition of the prepared MIP electrochemical sensor to the quantification of 5-HT in biological samples with high selectivity and recovery.
Highlights
Electrochemical sensors based on metal nanoparticles and molecularly imprinted polymer (MIP) composite are used in medical, pharmaceutical, agricultural, and environmental areas (Parnianchi et al, 2018)
After studying we found metal nanomaterials with specific catalytic activity and appropriate functional monomers can be used for sensing applications of MIP graphene composite, but we will discuss the effectiveness of modified MIP composite electrochemical sensors
The present study was performed to investigate the effect of metal nanoparticles trapped in a polymer matrix on the performance of an electrochemical sensor for 5-HT detection in biological samples
Summary
Electrochemical sensors based on metal nanoparticles and MIP composite are used in medical, pharmaceutical, agricultural, and environmental areas (Parnianchi et al, 2018). Metal nanoparticles are mine productions such as iron and gold deposits that, after extraction and separation, are used broadly in electrochemical sensors for 5-HT detection in human blood and urine samples (Gholamnejad et al, 2020). One of the most wellknown neurotransmitters is 5-HT in serotonergic neurons and the effects on the growth and proliferation of brain neurons (Wu et al, 2019). The serotonergic system is vital in the regulation of virtually all brain functions, and dysregulation of the serotonergic system is associated with the pathogenesis of many psychiatric and neurological disorders (Murphy et al, 2006). The 5-HT syndrome due to drug interactions is very familiar with mild symptoms of life-
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