Abstract
Microfluidics technology is trustworthy for microparticle operation as it doesn't involve destructive contact. Our research endeavors have encompassed microparticles manipulation by generating swirling flow region (SFR). Now we try to utilize swirl and flow topology to promote microfluidic chip design because serial operation is still not well enabled. Herein, a new model is proposed for a 6-microchannel microfluidic chip, which has realized active control of microparticles. The chip is capable of trapping, transferring, and enriching microparticles, and is applied for microparticles sorting. Simulation is performed to substantiate the viability of generating SFRs, and experiments are conducted on 3D-printed chips to validate the envisioned functions of the proposed microfluidic chip. Encouragingly, our experiments yield convincing outcomes, wherein microparticles are successfully trapped, transferred, and enriched in separated SFRs. With the help of a self-developed vision algorithm, the size sorting of microparticles is facilitated. Significantly, the manipulation of different microparticles can be achieved by tuning the microchannel velocities and tailoring the flow topology. This work presents a pioneering flow field structure and provides a feasible scheme for sorting microparticles, which is a noteworthy advance in swirl-based microfluidic chip applications. It is a potential mean for bio-/chemical analysis and fluidic-directed assembly of multiple microparticles.
Published Version
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