Abstract
Angioimmunoblastic T-cell lymphoma (AITL) is now a well-established subtype of mature peripheral T-cell lymphoma (PTCL). Advanced-stage disease is common with uncharacteristic laboratory and autoimmune findings that often slow or mask the diagnosis. AITL afflicts advanced-age individuals with a median age of diagnosis of 65 years of age without a notable gender predisposition. Significant strides in the immunohistochemical and molecular signature of AITL have brought increased ability to diagnose this uncommon type of PTCL. The 2016 World Health Organization classification of lymphoid neoplasms recently acknowledged the complexity of this diagnosis with the addition of other AITL-like subsets. AITL now resides under the umbrella of nodal T-cell lymphomas with follicular T helper phenotype. The treatment of relapsed or refractory AITL remains an unmet need. The spectrum of AITL from diagnosis to treatment is reviewed subsequently in a fashion that may one day lead to personalized treatment approaches in a many-faced disease. Here we report a case of angioimmunoblastic T cell lymphoma which was diagnosed using endoscopic ultrasound guided fine needle biopsy. Our patient’s lab workup was unremarkable and inconclusive, but the correct diagnosis was established using endoscopic ultrasound guided fine needle biopsy. Chemotherapy started after diagnosis and his condition improved.
Published Version
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