Abstract
目的 观察应用大剂量胞磷胆碱对急性一氧化碳中毒迟发性脑病(DEACMP)的预防效应.方法 将186例中、重度急性一氧化碳中毒(COP)患者随机分为治疗组98例,对照组88例.两组患者在常规治疗的基础上,对照组应用胞磷胆碱注射液0.5 g配10%葡萄糖注射液300 ml静脉滴注,每日1次;治疗组将对照组的胞磷胆碱增至3.0 g外,余同对照组治疗.均21 d为1个疗程.在患者COP后第15、20、25、30、45,60天判定是否出现迟发性脑病.两组患者于入院第0、7、14、21天监测溶血磷脂酸(LPA)和酸性磷脂酸(AP)浓度变化.结果 治疗组出现迟发性脑病4例,占4.1%;对照组出现迟发性脑病11例,占12.5%,两组差异有统计学意义(P＜0.01).治疗组治疗后LPA、AP浓度较对照组明显降低(P＜0.01).结论 大剂量胞磷胆碱治疗COP,使其DEACMP发生率较常规剂量治疗明显降低,有显著的预防效应。
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