Abstract
A geroscience mouse model for Alzheimer's disease.
Highlights
Geroscience is a multidisciplinary field that examines the relationship between biological aging and agerelated diseases [1]
Seven processes discussed by the trans-NIH Geroscience Interest Group Summit that contribute to biological aging included macromolecular damage, epigenetic changes, inflammation, adaptation to stress, impairments to proteostasis, stem cell regeneration, and metabolism [2]
A major challenge for preclinical drug testing is the selection of an Alzheimer’s disease (AD) animal model
Summary
Geroscience is a multidisciplinary field that examines the relationship between biological aging and agerelated diseases [1]. A geroscience mouse model for Alzheimer’s disease These processes are highly integrated with one another such that targeting them as a group may be an effective approach to developing therapies to prevent or delay age-related disease.
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