Abstract
Salmonella typhimurium (S. typhimurium) is a major foodborne pathogen that poses a potentialrisk to public health. The development of biosensors that are specific, sensitive, and easy to manipulate can greatly reduce the potential risk posed by S. typhimurium. A robust, highly sensitive and specific fluorescent biosensor was proposed by combining N-succinyl-chitosan-doped surface bacterial cell imprinted film (SCIF) with typical aggregation induced emission (AIE) fluorescent substance Au(I)-disulfide nanoparticles. The proposed fluorescent sensor can achieve linear detection of S. typhimurium in the concentration range from 10 to 106 CFU/mL with a detection limit of 4 CFU/mL. In addition, the modification of the SCIF on the surface enables specific abiotic recognition of the target bacteria. This fluorescence sensing strategy can be used for the detection of S. typhimurium in chicken meat samples. The platform can be replicated for the detection of other bacteria or cells via making different SCIFs, which is promising for the detection of practical samples for clinical and biological applications.
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