Abstract
Vitamin B9 or folic acid is an important food supplement with wide clinical applications. Due to its importance and its side effects in pregnant women, fast determination of this vitamin is very important. In this study we present a new fast and sensitive voltammetric sensor for the analysis of trace levels of vitamin B9 using a carbon paste electrode (CPE) modified with 1,3-dipropylimidazolium bromide (1,3-DIBr) as a binder and ZnO/CNTs nanocomposite as a mediator. The electro-oxidation signal of vitamin B9 at the surface of the 1,3-DIBr/ZnO/CNTs/CPE electrode appeared at 800 mV, which was about 95 mV less positive compared to the corresponding unmodified CPE. The oxidation current of vitamin B9 by square wave voltammetry (SWV) increased linearly with its concentration in the range of 0.08–650 μM. The detection limit for vitamin B9 was 0.05 μM. Finally, the utility of the new 1,3-DIBr/ZnO/CNTs/CPE electrode was tested in the determination of vitamin B9 in food and pharmaceutical samples.
Highlights
Interest in voltammetric sensors for fast analysis has increased in the recent years [1,2,3,4,5], but the high overvoltage and low electrical signal of electroactive compounds, especially in food, pharmaceutical, biological and environmental samples, is problematic for the application of voltammetric sensors [6,7,8,9,10,11,12]
The results indicated that the oxidation for bare carbon paste electrode (CPE), ZnO/CNTs/CPE and 1,3-DIBr/CPE was subsequently exploited as an electrochemical peak currents of vitamin B9 at 1,3-DIBr/ZnO/CNTs/CPE can be significantly enhanced, so it’s sensor for effective sensing of vitamin B9
The results show that the peak current increased linearly as the square root of scan rate increased by ~2.83 times at the 1,3-DIBr/ZnO/CNTs/CPE surface compared to CPE
Summary
Interest in voltammetric sensors for fast analysis has increased in the recent years [1,2,3,4,5], but the high overvoltage and low electrical signal of electroactive compounds, especially in food, pharmaceutical, biological and environmental samples, is problematic for the application of voltammetric sensors [6,7,8,9,10,11,12]. Nanotechnology and nanoscience represent new and enabling platforms that promise to provide a broad range of novel uses and improved technologies for environmental, biological and other scientific applications [31,32,33,34,35,36,37,38,39] Nanomaterials have been another acceptable choice for the modification of electrochemical sensors in recent years [40,41,42,43,44,45]. The obtained results showed the superiority of 1,3-DIBr/ZnO/CNTs/CPE over unmodified electrodes in terms of better reversibility and higher sensitivity
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