Abstract
Baroreceptor is the feedback unit present in the living beings which acts as a sensor that is located in the walls of blood vessels. This sensor senses the deformation in the blood vessels which causes change in arterial blood pressure and regulates it via Central Nervous System (CNS) and the information are autonomic reflexes that has a great influence on circulatory system elements such as peripheral systemic resistance (Rpsym), contractility of the ventricles (Emax), unstressed volume of the ventricles (Vus_ven) and heart rate (HR). The dynamic behaviour of the baroreceptor is modeled and substantiated by applying the negative feedback mechanism. A detailed modeling and simulation study is presented considering various testing conditions in regulating the circulatory system elements which oversees the Mean Arterial Pressure (MAP) in cardiovascular system. The Total Artificial Cardiovascular model (TAH-CVS) is also developed using pressure, volume and flow related differential equations. Based on the testing conducted under various conditions, the feedback-mechanism of the baroreceptor model is combined with the continuous TAH-CVS closed loop model to validate the effectiveness of the baroreceptor model. The simulation results of TAH-CVS model at initial conditions are compared with the TAH-CVS model with baroreceptor.
Highlights
There are several feedback loops present in the human body for maintaining hormone levels, blood sugar, temperature, pH and blood pressure
The feedback actions taken by baroreceptor are autonomic reflexes that
Baroreceptor is stretch receptor situated on the walls of the blood vessels, the most approachable of which are located in aortic arch and in the carotid sinus
Summary
There are several feedback loops present in the human body for maintaining hormone levels, blood sugar, temperature, pH and blood pressure. The control mechanism that shows an immediate effect in regulating the blood pressure is baroreceptor whereas the other mechanisms namely humoral, renal and tissue regulations are deliberate [1,2,3,4]. The feedback actions taken by baroreceptor are autonomic reflexes that. Revised Manuscript Received on December 30, 2019. * Correspondence Author Sowparnika G C*, Department of Chemical Engineering, Coimbatore.
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