Abstract
Objective To investigate error-related negativity characteristics of patients with internalizing mental disorders and its diagnostic value. Methods Fifty-five patients met with DSM-IV anxiety or depression criteria were sampled from outpatients and inpatients, and 20 normal adults were selected as control group. With Eriksen and Simon tasks as evoked stimuli, error-related negativities of each participant were acquired using Canada Stellate-64 channel EEG/ERP Instrument and BESA5.2 software, and the data of general information, clinical symptoms, reaction time, and error rate were collected. Results (1) Correct reaction time ((377.5±98.8)ms) and errors reaction time ((337.3±96.6)ms) of patient group were significantly longer than those of control group ((288.5±105.9)ms and (281.9±94.3)ms) on the Eriksen task and Simon task, and there were no significantly group differences on other indicators (P>0.05). (2) ERN amplitudes at 6 sities (Fz=(4.97±5.74)μV, F3=(5.50±4.59)μV, F4=(6.26±6.79)μV, Cz=(4.74±5.51)μV, C3=(5.44±4.8)μV, C4=(5.50±5.28)μV) of patients group were significantly greater than those of control group ((1.17±1.47)μV, (2.22±3.95)μV, (3.40±2.55)μV, (2.28±1.41)μV, (3.05±2.47)μV, (3.16±2.51)μV) on the Eriksen task.ERN amplitudes at Fz((5.43±6.61)μV) and F4((6.00±5.50)μV) of patient group were significantly were greater than those of control group ((2.05±2.34)μV, (3.09±2.86)μV) on the Simon task, and there were no significantly group differences on the ERN amplitudes at other sites (P>0.05). (3) ERN latencies ((87.6±34.4)ms and (84.9±34.8)ms)of patient group at Fz and F4 were significantly longer than control group ((54.0±46.5)ms and (36.3±42.4)ms) on the Simon task, and there were no significantly group differences on the ERN latencies at other sites (P>0.05). Conclusion The increased error related potentials suggest that patients with internalizing mental disorders has an internal error monitoring defects, and ERN might be a useful endophenotype for internalizing mental disorders. Key words: Error-related negativity; Internalizing mental disorders; Endophenotype
Published Version
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