Abstract

Objective To explore the effect of aging on the brain electrophysiological mechanism of information processing of representation rotating in patients with depressive disorder.Methods Twenty-seven patients with depressive disorders,admitted to our hospital from November 2011 and March 2011,were chosen in our study and they were divided into young-aged group (n=14) and old-aged group (n=13); and other 26 normal healthy participants (13 in young-aged group and 13 in old-aged group) were also chosen; they were performed the mental rotation tasks; the latency and amplitude of P500,and the wrong number and the response time by event-related potentials (ERP) system were measured.Results As compared with the control group,the patients in the young and old-aged patient group had higher error rates in normal and in lower error rates in mirror (P＜0.05),and longer reaction times in normal and longer reaction times in mirror (P＜0.05).As compared with the control group,the patients in the young and old-aged patient group had lower P500 amplitude in normal and higher P500 amplitude in mirror (P＜0.05); the P500 latency in the young-aged patient group was longer than that in the old-age patient group (P＜0.05).As compared with the young-aged control group,the error rates in the old-age control group were higher (P＜0.05),the reaction times were longer (P＜0.05),the P500 amplitude was lower (P＜0.05),and P500 latency was longer in the old-aged control group(P＜0.05); no significant difference was found on the error rates,reaction times,P500 amplitude and latency in the old-aged patients group (P＞0.05).Conclusion The information processing of representation rotating is impaired in patients with depressive disorder,and its aging effect disappears; the young-aged patients has a greater extent of damage than the elderly patients; it is suggested that the aging brain nerve system in a certain degree can protect the system on information processing of representation rotating. Key words: Depressive disorder; Representation; Information processing; Aging effect; Mental rotation; Event-related potential

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.