Abstract
Malaria, a life-threatening disease, is caused by parasitic single-celled microorganisms. It is specifically transmitted by the anopheles female mosquito of the Plasmodium family. There are a lot of drugs available in the market to treat this life-challenging disease. Chloroquine, a cheaper molecule that is available worldwide, is one of them. Drug resistance has been observed with chloroquine as well as with some other quinine derivatives and with artemisinin derivatives in the southeast region of Asia in countries like Cambodia, Thailand, Myanmar, and Vietnam country since 1957. After 1970, the drug resistance has been further increased and it has been expanded in several localities of India. Also, antimalarial agents, particularly chloroquine, have so many side effects such as nausea, vomiting, blurred vision, abdominal cramps, diarrhea, headache, appetite loss, deprivation of hearing, skin color change, baldness, reduced body weight, and seizures. Furthermore, this drug cannot be given to pregnant women. Hence, it is the right time to design and develop newer antimalarial agents so that this kind of drug resistance, as well as side effects of the drugs, can be overcome.
Highlights
Malaria is a life-threatening infectious disease that occurs due to biting of anopheles female mosquito
Paquet et al have screened a small molecule library against human P. falciparum parasite and invented a newer 2-aminopyridine derivative, MMV390048, which was active against multiple parasite life cycle stages. They have reported that the drug is active against drug resistant parasites. They have summarized the molecular mechanism of this drug which blocks the phosphatidylinositol 4-kinase (PI4K) and stated that this drug may be used for malaria control as a single dose combination treatment.[9]
Duparc et al have reported that tafenoquine, an 8-aminoquinoline antimalarial drug has been approved as a single-dose therapy (300 mg) for prevention of P. vivax relapse when coadministered with chloroquine
Summary
Malaria is a life-threatening infectious disease that occurs due to biting of anopheles female mosquito. Drug resistance, malaria, P. falciparum, prophylaxis, treatment
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
