Abstract
The Other Face of Artesunate: Southern Drug to Treat Northern Diseases
Highlights
Malaria Research Unit, SMITH, ICBMS, UMR 5246 CNRS-INSA-CPE-UCBL1, University Lyon 1, France Institut of Parasitology and Medical Mycology, Hospices Civils de Lyon, France
They failed to demonstrate that artesunate restored apoptosis in cancer cells, but they observed a decrease expression of Ki67 prognosis marker of colorectal cancer (Krishna et al, 2014)
Evidence has emerged years ago that artemisinin derivatives (ARTs) present a wide range of biological activities based on their alkylating capabilities, and may be effective against cancer cells by induction of cell apoptosis caused by reactive oxygen species production and angiogenesis inhibition (HamacherBrady et al, 2011)
Summary
Malaria Research Unit, SMITH, ICBMS, UMR 5246 CNRS-INSA-CPE-UCBL1, University Lyon 1, France Institut of Parasitology and Medical Mycology, Hospices Civils de Lyon, France. In this issue of EBioMedicine, Sanjeev Krishna and colleagues compared oral artesunate to placebo to treat colorectal cancer (Krishna et al, 2014). While the number of included patients was limited, they found a trend to higher recurrence-free survival probability at 42 months of follow-up after artesunate treatment. This double-blinded trial provides further evidence that artemisinin derivatives (ARTs) are antimalarial drugs.
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