Abstract
BackgroundPapillary thyroid carcinoma (PTC) is one of the most common malignant carcinomas in the endocrine system, and it has a growing incidence worldwide. Despite the development of diagnosis and treatment modalities for thyroid carcinoma, the outcome remains uncertain. Autophagy participates in the process of cancer invasion, malignancy, metastasis, and drug resistance. Emerging research has shown that long noncoding RNAs (lncRNAs) play an important role in the process of different types of cancers. However, the interaction between the process of autophagy and lncRNA and the value of autophagy-related lncRNA for risk assessment, prediction of drug sensitivity, and prognosis prediction in PTC patients remains unknown.Materials and MethodsWe screened 1,283 autophagy-related lncRNAs and identified 144 lncRNAs with prognostic value in The Cancer Genome Atlas (TCGA) cohorts. Univariate and multivariate Cox regression analyses were used to establish the prognosis-related autophagy-related lncRNA risk classification consisting of 10 lncRNAs to indicate the level of risk, according to which the patients were grouped into high-risk group and low risk-group.ResultsThe high-risk group had dramatically worse overall survival compared with the low-risk group. Cox regression analysis was performed to confirm the independent prognostic value of the autophagy-related lncRNA risk stratification, and the time-dependent receiver operating characteristic curves of the risk stratification were 0.981 (1 year), 0.906 (3 years), and 0.963 (5 years). LncRNA CRNDE (LINC00180) is overexpressed in the tumor, and its high expression matched with poorer survival state. So, we chose it for further experiment. Finally, knockdown of the CRNDE in PTC increased the sensitivity to sorafenib.ConclusionCollectively, we successfully established a novel risk stratification for PTC based on the expression profiles of autophagy-related lncRNAs.
Highlights
Thyroid carcinoma is the most common endocrine malignant tumor, and 90% of this tumor type is made up of papillary carcinoma histologically [1]
Construction of a Prognostic Model. These optional long noncoding RNA stemness score (RNAss) (lncRNAs) were submitted to the step to construct the prognostic risk stratification of autophagy-related
The high occurrence of thyroid cancer has been shown to have a close relationship with daily iodine intake and disorders of thyroid-stimulating hormone (TSH) levels, and a strong association was proven that some Papillary thyroid carcinoma (PTC) patients exposited to ionizing radiation [23]
Summary
Thyroid carcinoma is the most common endocrine malignant tumor, and 90% of this tumor type is made up of papillary carcinoma histologically [1]. Papillary carcinoma accounts for most of the increase [3]. With the research on papillary carcinoma mainly focused on genetics, transcriptomics proteomics, and epigenetics, mechanistic knowledge is growing rapidly. Papillary thyroid carcinoma (PTC) is one of the most common malignant carcinomas in the endocrine system, and it has a growing incidence worldwide. Autophagy participates in the process of cancer invasion, malignancy, metastasis, and drug resistance. The interaction between the process of autophagy and lncRNA and the value of autophagy-related lncRNA for risk assessment, prediction of drug sensitivity, and prognosis prediction in PTC patients remains unknown
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