Abstract
There were no systematic researches about autophagy-related long noncoding RNA (lncRNA) signatures to predict the survival of patients with colon adenocarcinoma. It was necessary to set up corresponding autophagy-related lncRNA signatures. The expression profiles of lncRNAs which contained 480 colon adenocarcinoma samples were obtained from The Cancer Genome Atlas (TCGA) database. The coexpression network of lncRNAs and autophagy-related genes was utilized to select autophagy-related lncRNAs. The lncRNAs were further screened using univariate Cox regression. In addition, Lasso regression and multivariate Cox regression were used to develop an autophagy-related lncRNA signature. A risk score based on the signature was established, and Cox regression was used to test whether it was an independent prognostic factor. The functional enrichment of autophagy-related lncRNAs was visualized using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. Ten prognostic autophagy-related lncRNAs (AC027307.2, AC068580.3, AL138756.1, CD27-AS1, EIF3J-DT, LINC01011, LINC01063, LINC02381, AC073896.3, and SNHG16) were identified to be significantly different, which made up an autophagy-related lncRNA signature. The signature divided patients with colon adenocarcinoma into the low-risk group and the high-risk group. A risk score based on the signature was a significantly independent factor for the patients with colon adenocarcinoma (HR = 1.088, 95%CI = 1.057 − 1.120; P < 0.001). Additionally, the ten lncRNAs were significantly enriched in autophagy process, metabolism, and tumor classical pathways. In conclusion, the ten autophagy-related lncRNAs and their signature might be molecular biomarkers and therapeutic targets for the patients with colon adenocarcinoma.
Highlights
Colorectal cancer (CRC) ranked third in incidence and second in mortality of all types of cancers worldwide [1]
We aimed to utilize The Cancer Genome Atlas (TCGA) database to establish autophagy-related long noncoding RNA (lncRNA) signatures and seek new biomarkers to predict the prognosis of the patients with colon adenocarcinoma
We explored the functional enrichment of autophagy-related lncRNAs with a prognostic value and visualized the top 5 Gene Ontology (GO) and the Kyoto
Summary
Colorectal cancer (CRC) ranked third in incidence and second in mortality of all types of cancers worldwide [1]. Antineoplastic protocols included endoscopic and surgical local excision, radiotherapy and systemic treatment, local ablative therapies, targeted therapy, immunotherapy, and palliative chemotherapy [3]. These treatments had dramatic progress, the 5-year relative survival rate for colon cancer was 64% [2]. A multistep lysosomal degradation process which promoted metabolic adaptation and nutrient circulation, has been widely studied and demonstrated to be involved in cancer development [5]. In both physiological and pathological situations, autophagy is central to the maintenance of organismal homeostasis.
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