Abstract
Thyroid cancer (TC) is the most common malignancy of the endocrine system and its incidence is gradually rising. Research has demonstrated a close link between autophagy and thyroid cancer. We constructed a prognostic model of autophagy-related long non-coding RNA (lncRNA) in thyroid cancer and explored its prognostic value. The data used in this study were all obtained from The Cancer Genome Atlas (TCGA) database and the Human Autophagy Database (HADb). We construct a co-expression network by autophagy-related genes and lncRNA to obtain autophagy-related lncRNAs. After univariate Cox regression analysis and multivariate Cox regression analysis, autophagy-related lncRNAs significantly associated with prognosis were identified. Based on the risk score of lncRNA, thyroid cancer patients are divided into high-risk group and low-risk group. A total of 14,142 lncRNAs and 212 autophagy-related genes (ATGs) were obtained from the TCGA database and the HADb, respectively. We performed lncRNA-ATGs correlation analysis and finally obtained 1,166 autophagy-associated lncRNAs. Subsequently, we conducted univariate Cox regression analysis and multivariate Cox regression analysis, nine autophagy-related lncRNAs (AC092279.1, AC096677.1, DOCK9-DT, LINC02454, AL136366.1, AC008063.1, AC004918.3, LINC02471 and AL162231.2) significantly associated with prognosis were identified. Based on these autophagy-related lncRNAs, a risk model was constructed. The area under the curve (AUC) of the risk score was 0.905, proving that the accuracy of risk signature was superior. In addition, multiple regression analysis showed that risk score was a significant independent prognostic risk factor for thyroid cancer. In this study, nine autophagy-related lncRNAs in thyroid cancer were established to predict the prognosis of thyroid cancer patients.
Highlights
Thyroid cancer is the most common malignant tumor of the endocrine system, ranking in 9th place for incidence in 2020, with a global incidence three times higher in women than in men[1, 2]
A total of 14,142 long noncoding RNA (lncRNA) and 212 autophagy-related genes were obtained from the the Cancer Genome Atlas (TCGA) database and Human Autophagy Database (HADb) database, respectively
To further assess the prognostic value of autophagy-related lncRNAs, we first performed a univariate Cox regression analysis, which resulted in 28 autophagy-related lncRNAs associated with prognosis (Table 1)
Summary
Thyroid cancer is the most common malignant tumor of the endocrine system, ranking in 9th place for incidence in 2020, with a global incidence three times higher in women than in men[1, 2]. Due to the development of diagnostic techniques and clinical treatment, the incidence of thyroid cancer has been steadily increasing, while it has a better prognosis and low mortality rate[3, 4]. Surgery is the preferred treatment for thyroid cancer, in most cases of thyroid cancer the 5-year survival rate can exceed 90%, with the exception of ATC, which has a higher mortality rate[8]. Autophagy can inhibit tumorigenesis in the initial stage of cancer, and it can promote tumor progression in the later stage of cancer[12, 13]. Autophagy has become a potential therapeutic target for cancer treatment[14]
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