Abstract
The carcinoembryonic antigen (CEA) was measured by radioimmunoassay (RIA) in the serum of patients with carcinoma of the ovary (100), cervix (100), and healthy controls (100). Two methods were used in the RIA for the precipitation of the CEA immune complex: (i) double antibody (DA), and (ii) ammonium sulfate (AS). The mean value of the controls was 14.67 ± 4.09 ng CEA/ml of serum using the DA technique. Based on the control's mean value +2 SD, there were 3% positive results in the control group, 16 and 19% positive results in the ovarian and cervical cancer groups, respectively. With the AS technique, all the control values were less than 1.5 ng CEA/ml of serum. This gave 20 and 3% positive results in the ovarian and cervical cancer groups, respectively. Although the assays (DA and AS) are comparable, the results show that only six ovarian and one cervical cancer patient had positive CEA levels, when determined by both the DA and AS techniques.
Published Version
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