Correlation of serum levels of SCC-Ag and CEA with the depth of tumor myometrium infiltration in patients with cervical cancer

Abstract

Objective To analyze the correlation of serum levels of squamous cell carcinoma antigen (SCC-Ag) and carcinoembryonic antigen (CEA) with the depth of tumor myometrium infiltration in patients with cervical cancer. Methods Forty-three patients with cervical cancer were selected as cervical cancer group, and 43 patients with benign uterine lesions were selected as benign group. At the same time, 43 health examination subjects were selected as healthy group. In the fasting state, 3 ml venous blood was extracted from all subjects, and the serum was separated for preparation. The serum levels of SCC-Ag and CEA were determined by enzyme-linked immunosorbent assay. The serum levels of SCC-Ag and CEA were compared cross three groups and among cervical cancer patients with different depths of tumor myometrium infiltration to analyze the correlation between the levels of serum SCC-Ag and CEA and the depth of tumor myometrium infiltration. Results The difference in levels of serum SCC-Ag and CEA among the three groups was statistically significant (P 1/2 were higher than those in patients with myometrium infiltration≤1/2, and the difference was statistically significant (P<0.05). The Pearson test showed that there was a significant positive correlation between the levels of serum SCC-Ag and CEA and the depths of myometrium infiltration in cervical cancer patients (r1=0.752, r2=0.821, P<0.05). Conclusions The levels of serum SCC-Ag and CEA are positively correlated with the depths of myometrium infiltration in cervical cancer patients. In clinical, treatment protocol could be made and adjusted according to levels of SCC-Ag and CEA, which has a great significance in clinical treatment. Key words: Cervical cancer; Depth of tumor myometrium infiltration; Carcinoembryonic antigen; Squamous cell carcinoma antigen