Abstract
Objective To compare the safety and efficacy of intravaginal prostaglandin E1, misoprostol with ricinus oil meal for labor induction. Methods 120 patients with an indication for induction of labor were randomly assigned to two groups (60 cases each) induction with misoprotol, 50μg intravaginally every 3 hours until active labor, or with that ricinus oil meal was taken. Results The time from start of intuction to vaginal deliery was significantly shorter than in the misoprostol group [(12.2±3.5)h vs (18.1±3.2)h] (P<0.05), and fewer patients in the misoprostol group required oxytocin augmentation (10% vs 40%, P<0.05). The mean change in the Bishop score was significantly higher than in those receiving misoprotol (5.5 vs 3.1, P<0.05). Uterine tachysystole occurred more frequently in patients in the misoprostol group (16.7%) than in the ricinus oil meal group (3.0%). No significant difference was noted in the mode of delivery and patients of successful labor induction. Conclusion Vaginally administered misoprostol is an effective agent for the cervical ripening and induction of labor. Key words: Misoprotol; Labor induced
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