Abstract
Today, there are over 2,000 different biomaterials used for various medical applications, but none of these biomaterials are 100% compatible with all human beings. Coconut fiber is widely available but has not been tested as a safe natural alternative for sutures. Immature coconut fiber is nonabsorbable and is effective for cuts and open wounds when used in combination with dehydrated human amnion membrane (dHAM). Immature coconut fiber, tamarind seed polysaccharide (TSP), and dHAM were prepared to test their combinational effect on wound healing in rats. TSP enhanced cell viability, proliferation, and migration in human skin cells and cured wounds both individually and in combination with dHAM. An antibiotic-free combination of the human amniotic membrane with intact epithelium, tamarind seed polysaccharide, and immature coconut fiber provided faster wound healing. Significantly higher wound healing was seen on the 11th day based on an initial 10 mm biopsy punch surgery in Wistar rats compared to control groups. Histological studies revealed thickened dermis edges with more neutrophil infiltration. Collagen deposition in the dermis was homogeneous across the excised skin tissue in the test group, again attesting to the utility of this procedure. This research signifies the use of TSP gel together with the amnion membrane representing a “smart patch” with wound healing potential, which would encourage further research on the smart patch made using a combination of plant and animal biological materials.
Highlights
Wound healing is a natural and complex process of tissue recovery of injured tissues involving growth factors and cytokines, released at the injured site
Wound dressings made of pectin and collagen enhance wound healing but are highly expensive [4]
Preparation of Immature Coconut Fiber Suture. e fiber of green coconuts was removed from the shell of the nut and was soaked in water for 24 to 48 hours to allow the fiber to be separated into strands. e fiber strands are soaked into 70% isopropyl alcohol for decolourization for 5 hours and dried in a hot air oven between 40 and 50°C for 1 hour
Summary
Wound healing is a natural and complex process of tissue recovery of injured tissues involving growth factors and cytokines, released at the injured site. Delayed or impaired wound healing may occur due to several reasons like chronic medical conditions and medications that inhibit the healing process [1]. Medicinal plants with wound healing properties have been used to treat acute and chronic wounds for the past three decades [2, 3]. 70 to 80% depend on medicinal plants for the management of various ailments since ancient time [3]. Wound dressings made of pectin and collagen enhance wound healing but are highly expensive [4]. Identification of potent and effective natural compounds for wound healing would benefit in the management of wounds in a cost-effective manner
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