Abstract
Objective To explore the safety and feasibility of VOLUVEN and HES used for acute hypervolemic hemodilution on selective Hepatectomy. Methods 42 patients （ASA Ⅰ - Ⅱ ） were randomized to the two groups （ Ⅰ , VOLUVEN group; Ⅱ , HES group） ,20 minutes before the operation, the two groups of patients underwent AHH with VOLUVEN and HES respectively at the same quantity and speed, and then the changes of haemodynamics, blood gas analysis,electrolyte and coagulation indexes were detected. Results In I group,the changes of HB,HCT, PLT,central venous pressure had statistical significance before and after AHH（ t = 7. 880,32. 257,7. 303,22. 812, all P = 0.000）. In Ⅱ group,the changes of HB, HCT, PLT, central venous pressure had statistical significance before and after AHH （ t = 5. 398,14.924,11. 171,5. 620, all P = 0. 000）. For inter-group, VOLUVEN has less effect than HES on central venous pressure （t = 2. 367,P = 0： 023）. Conclusion Using VOLUVEN or HES can keep hemodynamics stable and improve the ischemic tolerance for AHH in liver surgery. VOLUVEN has less effect on central venous pressure Key words: Hemodilution; Blood substitutes
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