Abstract
BackgroundIn our continued search for bioactive compounds from plants, conscious effort is being made to rapidly analyze ethnobotanical plants used for treating various ailments by traditional healers before this information is irrevocably lost as societies advance and rural communities become urbanized.ResultsA compound isolated from the aqueous extract of Pavetta crassipes leaves showed activity against some pathogenic microorganisms which included Streptococcus pyogenes, Corynebacterium ulcerans, Klebsiella pneumoniae, Neisseria gonorrhoeae, Pseudomonas aeruginosa, and Escherichia coli at a concentration < 50 mg/mL. The compound had minimum inhibitory concentration ranging from 6.25 to 12.5 mg/mL and minimum bactericidal concentration ranging from 12.5 to 25 mg/mL. The compound was identified using 1D and 2D NMR experiments and comparison with literature data as quercetin-3-O-rutinoside.ConclusionsThis has supported the ethnomedicinal use of the plant, confirmed its activity, and has also provided an easy and simple method for isolating this compound which has a lot of pharmaceutical and cosmetic applications from a new source.
Highlights
In our continued search for bioactive compounds from plants, conscious effort is being made to rapidly analyze ethnobotanical plants used for treating various ailments by traditional healers before this information is irrevocably lost as societies advance and rural communities become urbanized
We report the isolation and characterization of a bioactive compound from the leaves of P. crassipes and its antimicrobial properties
Antimicrobial screening The results of the antimicrobial studies showed that the compound had a remarkable activity at 50 mg/mL against six of the ten microorganisms tested
Summary
In our continued search for bioactive compounds from plants, conscious effort is being made to rapidly analyze ethnobotanical plants used for treating various ailments by traditional healers before this information is irrevocably lost as societies advance and rural communities become urbanized. The available knowledge on the use of plant preparations in traditional medicine is enormous but if this is not rapidly researched, indications as to the usefulness of this vegetable treasure-house will be lost with succeeding generations [1]. Africa is reputed for the extraordinary richness of its flora, totalling several tens of thousands of species. Environmental degradation provides a threat to biological diversity, but the sub-Saharan region still boasts of a wide variety of indigenous species. Based on careful observation and a judicious choice of plants, it is possible to discover interesting new natural products [2]
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