Abstract
In this chapter, the detection principles and fabrication methods of optofluidic devices are discussed. Optofluidic devices enable synergistic operations of optics and microfluidics over a unified platform, resulting in precise and quantitative examination of biological samples such as cells, proteins, and nucleic acids. To address the emerging needs for point-of-care in vitro diagnostics, a variety of optofluidic devices have been developed to isolate, detect, or image cells and molecules. Lab-on-a-chip devices based on optofluidic technologies are adept for personalized healthcare, holding promise for reduced cost and improved efficacy. Very recently, incorporation of portable optofluidic devices into mobile devices such as smart phones has presented particularly promising opportunities for telemedicine and point-of-care clinics for low- and medium-income countries.
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