Abstract
Despite the large number of compounds available for the inhibition or the stimulation of autonomic functions, the number of case reports of poisoning, not side effects, involving such substances is fairly limited with maybe the exception of drugs blocking β-adrenergic receptors. This chapter focuses mainly on drugs that affect more specifically the autonomic nervous system and treatment of patients intoxicated with various types of such drugs. The toxic manifestations induced by overdoses of sympathomimetic drugs, such as epinephrine, dopamine, and norepinephrine, result from an accentuation of their pharmacological properties. Drugs that affect primarily the alpha-adrenergic receptors may induce mydriasis, vasoconstriction, coronary dilatation, bladder contraction, and decrease gastrointestinal motility. Miosis, vasodilatation, bronchodilatation, hyperglycemia, decreased gastrointestinal motility, bladder relaxation, and rennin release are physiological effects that can be noted following the stimulation of β2-adrenergic receptors.
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