Abstract
DNA strand displacement, which plays a fundamental role in DNA computing, has been widely applied to many biological computing problems, including biological logic circuits. However, there are many biological cascade logic circuits with domain labels based on DNA strand displacement that have not yet been designed. Thus, in this paper, cascade 8-bit adder/subtractor with a domain label is designed based on DNA strand displacement; domain t and domain f represent signal 1 and signal 0, respectively, instead of domain t and domain f are applied to representing signal 1 and signal 0 respectively instead of high concentration and low concentration high concentration and low concentration. Basic logic gates, an amplification gate, a fan-out gate and a reporter gate are correspondingly reconstructed as domain label gates. The simulation results of Visual DSD show the feasibility and accuracy of the logic calculation model of the adder/subtractor designed in this paper. It is a useful exploration that may expand the application of the molecular logic circuit.
Highlights
Biological computing has become a new hotspot due to DNA molecules having the advantages of parallelism, low energy consumption, and high storability in dealing with massive information; DNA nanotechnology stands out DNA nanotechnology has potential applications in biological calculations
This paper is arranged as follows: the development of DNA molecule logic circuits is introduced in the first part; the background of DNA strand displacement and logic gates is presented in the second part; a brief method for building domain label logic gates is presented in the third part; the simulation of the domain label cascade 8-bit adder/subtractor by Visual DSD is presented in the fourth part; and the fifth part presents the conclusions of this paper
Since the domain-labeled fluorescent signal chain cannot react with other logic gates just to facilitate detection, the removal of the detection gate does not affect the result of the reaction, so detection gates are removed from semi-adder and full adder, and only the A domain-labeled detection gate is added to the final output of the multiplier to facilitate the detection of the eight domain tag output signal strands
Summary
Biological computing has become a new hotspot due to DNA molecules having the advantages of parallelism, low energy consumption, and high storability in dealing with massive information; DNA nanotechnology stands out DNA nanotechnology has potential applications in biological calculations. The innovation of this paper is that the design of the molecular domain label is used in the logic gates, where logical results are detected through the labeling of the domain label with a fluorescent label in the reaction solution This was not seen in the previous design of the molecular logic circuit, and this paper broadens the range of input signals with DNA molecules to construct the logic circuit. This paper is arranged as follows: the development of DNA molecule logic circuits is introduced in the first part; the background of DNA strand displacement and logic gates is presented in the second part; a brief method for building domain label logic gates is presented in the third part; the simulation of the domain label cascade 8-bit adder/subtractor by Visual DSD is presented in the fourth part; and the fifth part presents the conclusions of this paper
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