Abstract
Chitosan biopolymer possesses several properties that make it advantageous as a biomaterial for biomedical applications, such as biocompatibility, biodegradability, and solubility in dilute aqueous acidic solvents. Chitosan micro- and nanoparticles have been investigated for potential use in diagnosis and treatment of many different diseases with applications of therapeutic delivery, tissue engineering, and bioimaging. In therapeutic delivery, micro- and nanoparticles provide significant improvements over traditional oral and intravenous methods of administration in terms of efficacy and ease of use. For efficacy and safety of therapeutic treatments, chitosan particles must possess biocompatibility after synthesis. This chapter describes several different techniques of chitosan micro- and nanoparticle preparation for numerous biomedical applications, including conventional methods and recently developed methods.
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