Abstract
This chapter discusses the clinical features and genetics of hereditary neuropathies. The hereditary motor and sensory neuropathy (HMSN) Types I and II are the most common hereditary neuropathies. HMSN I disorder is distinguished from HMSN II by markedly reduced motor nerve conduction velocities. HMSN I may be divided into autosomal dominant and autosomal recessive varieties, with little clinical differences between the two. The chapter discusses that HMSN II is generally milder and has a later onset than HMSN I. It has been found that one-quarter of their patients had onset of symptoms before the age of 10, and one-third had onset of symptoms after the age of 40. It is less common than in HMSN I to find the weakness progressing to the upper limbs, and reflexes in the arms are usually preserved. Spine and foot deformities are less common than in HMSN I.
Published Version
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