Abstract
Traditional cell culture techniques do not mimic natural tissue microenvironments, and therefore, do not provide physiologically relevant model systems. A promising approach to improve these systems is to mimic microenvironmental factors through the development and use of cell culture microdevices, with ultimate applications in cellular testing platforms and functional tissue replacements. We present an introduction and survey of this field in three sections beginning with a rationale for developing cell culture microdevices. Strategies for device fabrication are then discussed, followed by a review of applications for the use of these constructs.
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